Layered Double Hydroxide as a Potent Non-viral Vector for Nucleic Acid Delivery Using Gene-Activated Scaffolds for Tissue Regeneration Applications

• Main Authors: Lara S. Costard (Author), Domhnall C. Kelly (Author), Rachael N. Power (Author), Christopher Hobbs (Author), Sonia Jaskaniec (Author), Valeria Nicolosi (Author), Brenton L. Cavanagh (Author), Caroline M. Curtin (Author), Fergal J. O'Brien (Author)
• Format: Book
• Published: MDPI AG, 2020-12-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Nonviral vectors offer a safe alternative to viral vectors for gene therapy applications, albeit typically exhibiting lower transfection efficiencies. As a result, there remains a significant need for the development of a nonviral delivery system with low cytotoxicity and high transfection efficacy...