Role of Keap1-Nrf2 Signaling in Anhedonia Symptoms in a Rat Model of Chronic Neuropathic Pain: Improvement With Sulforaphane

• Main Authors: Shan Li (Author), Chun Yang (Author), Xi Fang (Author), Gaofeng Zhan (Author), Niannian Huang (Author), Jie Gao (Author), Hui Xu (Author), Kenji Hashimoto (Author), Ailin Luo (Author)
• Format: Book
• Published: Frontiers Media S.A., 2018-08-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Patients with chronic neuropathic pain frequently suffer from symptoms of anhedonia (loss of pleasure), which is a core clinical manifestation of depression. Accumulating studies have shown the beneficial effects of the natural compound sulforaphane (SFN), an activator of nuclear factor (erythroid-d...