Studies on the Reactions of Biapenem with VIM Metallo β-Lactamases and the Serine β-Lactamase KPC-2

Studies on the Reactions of Biapenem with VIM Metallo β-Lactamases and the Serine β-Lactamase KPC-2

Carbapenems are important antibacterials and are both substrates and inhibitors of some β-lactamases. We report studies on the reaction of the unusual carbapenem biapenem, with the subclass B1 metallo-β-lactamases VIM-1 and VIM-2 and the class A serine-β-lactamase KPC-2. X-ray diffraction studies wi...

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Main Authors: Anka Lucic (Author), Tika R. Malla (Author), Karina Calvopiña (Author), Catherine L. Tooke (Author), Jürgen Brem (Author), Michael A. McDonough (Author), James Spencer (Author), Christopher J. Schofield (Author)
Format: Book
Published: MDPI AG, 2022-03-01T00:00:00Z.
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