Studies on the Reactions of Biapenem with VIM Metallo β-Lactamases and the Serine β-Lactamase KPC-2

• Hoofdauteurs: Anka Lucic (Auteur), Tika R. Malla (Auteur), Karina Calvopiña (Auteur), Catherine L. Tooke (Auteur), Jürgen Brem (Auteur), Michael A. McDonough (Auteur), James Spencer (Auteur), Christopher J. Schofield (Auteur)
• Formaat: Boek
• Gepubliceerd in: MDPI AG, 2022-03-01T00:00:00Z.
• Onderwerpen: article
• Online toegang: Connect to this object online.

Carbapenems are important antibacterials and are both substrates and inhibitors of some β-lactamases. We report studies on the reaction of the unusual carbapenem biapenem, with the subclass B1 metallo-β-lactamases VIM-1 and VIM-2 and the class A serine-β-lactamase KPC-2. X-ray diffraction studies wi...