Composition Dependency of the Flory-Huggins Interaction Parameter in Drug-Polymer Phase Behavior

• Главные авторы: Jana Klueppelberg (Автор), Ulrich A. Handge (Автор), Markus Thommes (Автор), Judith Winck (Автор)
• Формат: ‌
• Опубликовано: MDPI AG, 2023-11-01T00:00:00Z.
• Предметы: article
• Online-ссылка: Connect to this object online.

An innovative strategy to address recent challenges in the oral administration of poorly soluble drugs is the formulation of amorphous solid dispersions (ASDs), where the drug is dissolved in a highly soluble carrier polymer. Therefore, special knowledge of the drug-polymer phase behavior is essenti...