Population pharmacokinetic analysis and dosage recommendations for digoxin in Japanese patients with atrial fibrillation and heart failure using real-world data

• मुख्य लेखकों: Toshinori Hirai (लेखक), Hidefumi Kasai (लेखक), Miyoko Naganuma (लेखक), Nobuhisa Hagiwara (लेखक), Tsuyoshi Shiga (लेखक)
• स्वरूप: पुस्तक
• प्रकाशित: BMC, 2022-02-01T00:00:00Z.
• विषय: article
• ऑनलाइन पहुंच: Connect to this object online.

Abstract Background Digoxin is an important treatment option for reducing the ventricular rate in patients with atrial fibrillation (AF) and heart failure (HF). Digoxin has a narrow therapeutic window and large interindividual variability. A low target blood concentration, especially ≤0.9 ng/mL, is...