Gli1 promotes epithelial-mesenchymal transition and metastasis of non-small cell lung carcinoma by regulating snail transcriptional activity and stability

• Main Authors: Xueping Lei (Author), Zhan Li (Author), Yihang Zhong (Author), Songpei Li (Author), Jiacong Chen (Author), Yuanyu Ke (Author), Sha Lv (Author), Lijuan Huang (Author), Qianrong Pan (Author), Lixin Zhao (Author), Xiangyu Yang (Author), Zisheng Chen (Author), Qiudi Deng (Author), Xiyong Yu (Author)
• Format: Book
• Published: Elsevier, 2022-10-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Metastasis is crucial for the mortality of non-small cell lung carcinoma (NSCLC) patients. The epithelial-mesenchymal transition (EMT) plays a critical role in regulating tumor metastasis. Glioma-associated oncogene 1 (Gli1) is aberrantly active in a series of tumor tissues. However, the molecular r...