MG53 Preserves Neuromuscular Junction Integrity and Alleviates ALS Disease Progression

• Main Authors: Jianxun Yi (Author), Ang Li (Author), Xuejun Li (Author), Kiho Park (Author), Xinyu Zhou (Author), Frank Yi (Author), Yajuan Xiao (Author), Dosuk Yoon (Author), Tao Tan (Author), Lyle W. Ostrow (Author), Jianjie Ma (Author), Jingsong Zhou (Author)
• Format: Book
• Published: MDPI AG, 2021-09-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Respiratory failure from progressive respiratory muscle weakness is the most common cause of death in amyotrophic lateral sclerosis (ALS). Defects in neuromuscular junctions (NMJs) and progressive NMJ loss occur at early stages, thus stabilizing and preserving NMJs represents a potential therapeutic...