Complement C5a Alters the Membrane Potential of Neutrophils during Hemorrhagic Shock

• Main Authors: David A. C. Messerer (Author), Stephanie Denk (Author), Karl J. Föhr (Author), Rebecca Halbgebauer (Author), Christian K. Braun (Author), Felix Hönes (Author), Julia Harant (Author), Michael Fauler (Author), Manfred Frick (Author), Benedikt L. Nußbaum (Author), Peter Radermacher (Author), Sebastian Hafner (Author), Markus S. Huber-Lang (Author)
• Format: Book
• Published: Hindawi Limited, 2018-01-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Background. Polymorphonuclear granulocytes (PMN) play a crucial role in host defense. Physiologically, exposure of PMN to the complement activation product C5a results in a protective response against pathogens, whereas in the case of systemic inflammation, excessive C5a substantially impairs neutro...