A mouse infection model and long-term lymphatic endothelium co-culture system to evaluate drugs against adult Brugia malayi.

• Main Authors: Amy E Marriott (Author), Julio Furlong Silva (Author), Nicolas Pionnier (Author), Hanna Sjoberg (Author), John Archer (Author), Andrew Steven (Author), Dale Kempf (Author), Mark J Taylor (Author), Joseph D Turner (Author)
• Format: Book
• Published: Public Library of Science (PLoS), 2022-06-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

The development of new drugs targeting adult-stage lymphatic filarial nematodes is hindered by the lack of a robust long-term in vitro culture model. Testing potential direct-acting and anti-Wolbachia therapeutic candidates against adult lymphatic filariae in vitro requires their propagation via chr...