Opioid therapy duration before naldemedine treatment is a significant independent risk of diarrhea: a retrospective cohort study

• Hoofdauteurs: Akiharu Okamoto (Auteur), Kenji Ikemura (Auteur), Eri Mizutani (Auteur), Takuya Iwamoto (Auteur), Masahiro Okuda (Auteur)
• Formaat: Boek
• Gepubliceerd in: BMC, 2021-02-01T00:00:00Z.
• Onderwerpen: article
• Online toegang: Connect to this object online.

Abstract Background The most common adverse event (AE) associated with opioid analgesics is opioid-induced constipation (OIC). Naldemedine (NAL) is widely used for the treatment of OIC. However, diarrhea has been reported as the most common treatment-emergent AE of NAL, and little is known about the...