A streamlined method for analysing genome-wide DNA methylation patterns from low amounts of FFPE DNA

• Auteurs principaux: Jackie L. Ludgate (Auteur), James Wright (Auteur), Peter A. Stockwell (Auteur), Ian M. Morison (Auteur), Michael R. Eccles (Auteur), Aniruddha Chatterjee (Auteur)
• Format: Livre
• Publié: BMC, 2017-08-01T00:00:00Z.
• Sujets: article
• Accès en ligne: Connect to this object online.

Abstract Background Formalin fixed paraffin embedded (FFPE) tumor samples are a major source of DNA from patients in cancer research. However, FFPE is a challenging material to work with due to macromolecular fragmentation and nucleic acid crosslinking. FFPE tissue particularly possesses challenges...