A redox-responsive self-assembling COA-4-arm PEG prodrug nanosystem for dual drug delivery suppresses cancer metastasis and drug resistance by downregulating hsp90 expression

• Main Authors: Yi Zhou (Author), Yingling Miao (Author), Qiudi Huang (Author), Wenwen Shi (Author), Jiacui Xie (Author), Jiachang Lin (Author), Pei Huang (Author), Chengfeng Yue (Author), Yuan Qin (Author), Xiyong Yu (Author), He Wang (Author), Linghao Qin (Author), Jianhai Chen (Author)
• Format: Book
• Published: Elsevier, 2023-07-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Metastasis and resistance are main causes to affect the outcome of the current anticancer therapies. Heat shock protein 90 (Hsp90) as an ATP-dependent molecular chaperone takes important role in the tumor metastasis and resistance. Targeting Hsp90 and downregulating its expression show promising in...