Efficient Induction of Antigen-Specific CD8⁺ T-Cell Responses by Cationic Peptide-Based mRNA Nanoparticles

• Main Authors: Sigrid D'haese (Author), Thessa Laeremans (Author), Sabine den Roover (Author), Sabine D. Allard (Author), Guido Vanham (Author), Joeri L. Aerts (Author)
• Format: Book
• Published: MDPI AG, 2022-06-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

A major determinant for the success of mRNA-based vaccines is the composition of the nanoparticles (NPs) used for formulation and delivery. Cationic peptides represent interesting candidate carriers for mRNA, since they have been shown to efficiently deliver nucleic acids to eukaryotic cells. mRNA N...