Optimizing a therapy for opiate use disorders: Characterizing ondansetron pharmacokinetics in blood and brain

• Egile Nagusiak: Manhong Wu (Egilea), Zhuanfen Cheng (Egilea), Anthony T. Le (Egilea), Yalun Tan (Egilea), Gary Peltz (Egilea)
• Formatua: Liburua
• Argitaratua: Wiley, 2023-02-01T00:00:00Z.
• Gaiak: article
• Sarrera elektronikoa: Connect to this object online.

Abstract Administration of a widely used 5‐hydroxytryptamine receptor (5HT3AR) antagonist (ondansetron) potently inhibited the development of experimentally induced opioid dependence and withdrawal responses in mice and humans. However, in several studies examining withdrawal symptoms in subjects wi...