Optimizing a therapy for opiate use disorders: Characterizing ondansetron pharmacokinetics in blood and brain

• Main Authors: Manhong Wu (Author), Zhuanfen Cheng (Author), Anthony T. Le (Author), Yalun Tan (Author), Gary Peltz (Author)
• Format: Knjiga
• Izdano: Wiley, 2023-02-01T00:00:00Z.
• Teme: article
• Online dostop: Connect to this object online.

Abstract Administration of a widely used 5‐hydroxytryptamine receptor (5HT3AR) antagonist (ondansetron) potently inhibited the development of experimentally induced opioid dependence and withdrawal responses in mice and humans. However, in several studies examining withdrawal symptoms in subjects wi...