Analysis of in vitro and in vivo metabolism of zidovudine and gemfibrozil in trans‐chromosomic mouse line expressing human UGT2 enzymes

• Main Authors: Kaoru Kobayashi (Author), Tsuneo Deguchi (Author), Satoshi Abe (Author), Naoyo Kajitani (Author), Kanako Kazuki (Author), Shoko Takehara (Author), Kazuomi Nakamura (Author), Atsushi Kurihara (Author), Mitsuo Oshimura (Author), Yasuhiro Kazuki (Author)
• Format: Book
• Published: Wiley, 2022-12-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Abstract UDP‐glucuronosyltransferases (UGTs) catalyze the conjugation of various substrates with sugars. Since the UGT2 family forms a large cluster spanning 1.5 Mb, transgenic mouse lines carrying the entire human UGT2 family have not been constructed because of limitations in conventional cloning...