Nalbuphine alleviates inflammation by down-regulating NF-κB in an acute inflammatory visceral pain rat model

• Main Authors: Dijiao Ruan (Author), Yuanyuan Wang (Author), Sisi Li (Author), Chao Zhang (Author), Wenwen Zheng (Author), Cong Yu (Author)
• Format: Book
• Published: BMC, 2022-06-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Abstract Introduction Nalbuphine can relieve patients' inflammation response after surgery compared to other opioid drugs. However, its molecular mechanism has not been clear. Activation of NF-κB signaling pathway under oxidative stress and inflammation can maintain pain escalation. Methods We...