Improve BBB Penetration and Cytotoxicity of Palbociclib in U87-MG Glioblastoma Cells Delivered by Dual Peptide Functionalized Nanoparticles

Palbociclib (PBC) is an FDA-approved CDK4/6 inhibitor used for breast cancer treatment. PBC has been demonstrated its ability to suppress the proliferation of glioma cells by inducing cell cycle arrest. However, the efflux transporters on the blood-brain barrier (BBB) restricts the delivery of PBC t...

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Main Authors: Yu-Chen Lo (Author), Wen-Jen Lin (Author)
Format: Book
Published: MDPI AG, 2023-10-01T00:00:00Z.
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3rd Floor Main Library

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Call Number: A1234.567
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