Tumor-targeted metabolic inhibitor prodrug labelled with cyanine dyes enhances immunoprevention of lung cancer

• Main Authors: Wen Li (Author), Jiali Huang (Author), Chen Shen (Author), Weiye Jiang (Author), Xi Yang (Author), Jingxuan Huang (Author), Yueqing Gu (Author), Zhiyu Li (Author), Yi Ma (Author), Jinlei Bian (Author)
• Format: Book
• Published: Elsevier, 2024-02-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Recent progress in targeted metabolic therapy of cancer has been limited by the considerable toxicity associated with such drugs. To address this challenge, we developed a smart theranostic prodrug system that combines a fluorophore and an anticancer drug, specifically 6-diazo-5-oxo-l-norleucine (DO...