High Efficacy and Drug Synergy of HDAC6-Selective Inhibitor NN-429 in Natural Killer (NK)/T-Cell Lymphoma

• Main Authors: Harsimran Kaur Garcha (Author), Nabanita Nawar (Author), Helena Sorger (Author), Fettah Erdogan (Author), Myint Myat Khine Aung (Author), Abootaleb Sedighi (Author), Pimyupa Manaswiyoungkul (Author), Hyuk-Soo Seo (Author), Susann Schönefeldt (Author), Daniel Pölöske (Author), Sirano Dhe-Paganon (Author), Heidi A. Neubauer (Author), Satu M. Mustjoki (Author), Marco Herling (Author), Elvin D. de Araujo (Author), Richard Moriggl (Author), Patrick T. Gunning (Author)
• Format: Book
• Published: MDPI AG, 2022-10-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

NK/T-cell lymphoma (NKTCL) and γδ T-cell non-Hodgkin lymphomas (γδ T-NHL) are highly aggressive lymphomas that lack rationally designed therapies and rely on repurposed chemotherapeutics from other hematological cancers. Histone deacetylases (HDACs) have been targeted in a range of malignancies, inc...