Genetic loss of AMPK-glycogen binding destabilises AMPK and disrupts metabolism

• Main Authors: Nolan J. Hoffman (Author), Jamie Whitfield (Author), Natalie R. Janzen (Author), Mehdi R. Belhaj (Author), Sandra Galic (Author), Lisa Murray-Segal (Author), William J. Smiles (Author), Naomi X.Y. Ling (Author), Toby A. Dite (Author), John W. Scott (Author), Jonathan S. Oakhill (Author), Robert Brink (Author), Bruce E. Kemp (Author), John A. Hawley (Author)
• Format: Book
• Published: Elsevier, 2020-11-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Objective: Glycogen is a major energy reserve in liver and skeletal muscle. The master metabolic regulator AMP-activated protein kinase (AMPK) associates with glycogen via its regulatory β subunit carbohydrate-binding module (CBM). However, the physiological role of AMPK-glycogen binding in energy h...