Targeting the IGF1R Pathway in Breast Cancer Using Antisense lncRNA-Mediated Promoter cis Competition

• Main Authors: Lingling Pian (Author), Xue Wen (Author), Lihua Kang (Author), Zhaozhi Li (Author), Yuanyuan Nie (Author), Zhonghua Du (Author), Dehai Yu (Author), Lei Zhou (Author), Lin Jia (Author), Naifei Chen (Author), Dan Li (Author), Songling Zhang (Author), Wei Li (Author), Andrew R. Hoffman (Author), Jingnan Sun (Author), Jiuwei Cui (Author), Ji-Fan Hu (Author)
• Format: Book
• Published: Elsevier, 2018-09-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Aberrant insulin-like growth factor I receptor (IGF1R) signaling pathway serves as a well-established target for cancer drug therapy. The intragenic antisense long noncoding RNA (lncRNA) IRAIN, a putative tumor suppressor, is downregulated in breast cancer cells, while IGF1R is overexpressed, leadin...