Targeting the IGF1R Pathway in Breast Cancer Using Antisense lncRNA-Mediated Promoter cis Competition

• Главные авторы: Lingling Pian (Автор), Xue Wen (Автор), Lihua Kang (Автор), Zhaozhi Li (Автор), Yuanyuan Nie (Автор), Zhonghua Du (Автор), Dehai Yu (Автор), Lei Zhou (Автор), Lin Jia (Автор), Naifei Chen (Автор), Dan Li (Автор), Songling Zhang (Автор), Wei Li (Автор), Andrew R. Hoffman (Автор), Jingnan Sun (Автор), Jiuwei Cui (Автор), Ji-Fan Hu (Автор)
• Формат: ‌
• Опубликовано: Elsevier, 2018-09-01T00:00:00Z.
• Предметы: article
• Online-ссылка: Connect to this object online.

Aberrant insulin-like growth factor I receptor (IGF1R) signaling pathway serves as a well-established target for cancer drug therapy. The intragenic antisense long noncoding RNA (lncRNA) IRAIN, a putative tumor suppressor, is downregulated in breast cancer cells, while IGF1R is overexpressed, leadin...