Comparative Study of Different Combinational Mucoadhesive Formulations of Sumatriptan-Metoclopramide

• Main Authors: Mitra Jelvehgari (Author), Hadi Valizadeh (Author), Sanam Ziapour (Author), Mahdieh Rahmani (Author), Seyed Hassan Montazam (Author), Saieede Soltani (Author)
• Format: Book
• Published: Tabriz University of Medical Sciences, 2016-03-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Purpose: Sumatriptan succinate (Sum) is a Serotonin 5- HT1 receptor agonist, used in the treatment of migraine. It is absorbed rapidly but incompletely when taken orally and underwent first - pass metabolism, resulting in a low bioavailability of about 15%. The aim was to design mucoadhesive buccal...