Increase of HO-1 Expression in Critically Ill COVID-19 Patients Is Associated with Poor Prognosis and Outcome

• Main Authors: Maria G. Detsika (Author), Ioanna Nikitopoulou (Author), Dimitris Veroutis (Author), Alice G. Vassiliou (Author), Edison Jahaj (Author), Stamatis Tsipilis (Author), Nikolaos Athanassiou (Author), Hariklia Gakiopoulou (Author), Vassilis G. Gorgoulis (Author), Ioanna Dimopoulou (Author), Stylianos E. Orfanos (Author), Anastasia Kotanidou (Author)
• Format: Book
• Published: MDPI AG, 2022-06-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Heme-oxygenase (HO)-1 is a cytoprotective enzyme with strong antioxidant and anti-apoptotic properties and previous reports have also emphasized the antiviral properties of HO-1, either directly or via induction of interferons. To investigate the potential role of HO-1 in patients with coronavirus d...