Norlichexanthone purified from plant endophyte prevents postmenopausal osteoporosis by targeting ERα to inhibit RANKL signaling

• Main Authors: Keqi Wang (Author), Yongyan Chen (Author), Shuo Gao (Author), Maosi Wang (Author), Mengmeng Ge (Author), Qian Yang (Author), Mingkai Liao (Author), Lin Xu (Author), Junjie Chen (Author), Zhiping Zeng (Author), Haifeng Chen (Author), Xiao-kun Zhang (Author), Ting Lin (Author), Hu Zhou (Author)
• Format: Book
• Published: Elsevier, 2021-02-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Although different types of drugs are available for postmenopausal osteoporosis, the limitations of the current therapies including drug resistances and adverse effects require identification of novel anti-osteoporosis agents. Here, we defined that norlichexanthone (NOR), a natural product, is a lig...