Low Magnitude of Compression Enhances Biosynthesis of Mesenchymal Stem Cells towards Nucleus Pulposus Cells via the TRPV4-Dependent Pathway

• Main Authors: Yibo Gan (Author), Bing Tu (Author), Pei Li (Author), Jixing Ye (Author), Chen Zhao (Author), Lei Luo (Author), Chengmin Zhang (Author), Zetong Zhang (Author), Linyong Zhu (Author), Qiang Zhou (Author)
• Format: Bog
• Udgivet: Hindawi Limited, 2018-01-01T00:00:00Z.
• Fag: article
• Online adgang: Connect to this object online.

Mesenchymal stem cell- (MSC-) based therapy is regarded as a promising tissue engineering strategy to achieve nucleus pulposus (NP) regeneration for the treatment of intervertebral disc degeneration (IDD). However, it is still a challenge to promote the biosynthesis of MSC to meet the requirement of...