Dose predictions for [177Lu]Lu-DOTA-panitumumab F(ab')2 in NRG mice with HNSCC patient-derived tumour xenografts based on [64Cu]Cu-DOTA-panitumumab F(ab')2 - implications for a PET theranostic strategy

Dose predictions for [177Lu]Lu-DOTA-panitumumab F(ab')2 in NRG mice with HNSCC patient-derived tumour xenografts based on [64Cu]Cu-DOTA-panitumumab F(ab')2 - implications for a PET theranostic strategy

Abstract Background Epidermal growth factor receptors (EGFR) are overexpressed on many head and neck squamous cell carcinoma (HNSCC). Radioimmunotherapy (RIT) with F(ab')2 of the anti-EGFR monoclonal antibody panitumumab labeled with the β-particle emitter, 177Lu may be a promising treatment fo...

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Main Authors: Anthony Ku (Author), Misaki Kondo (Author), Zhongli Cai (Author), Jalna Meens (Author), Min Rong Li (Author), Laurie Ailles (Author), Raymond M. Reilly (Author)
Format: Book
Published: SpringerOpen, 2021-08-01T00:00:00Z.
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3rd Floor Main Library

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