Mitochondrial membrane potential-enriched CHO host: a novel and powerful tool for improving biomanufacturing capability

• Main Authors: Lina Chakrabarti (Author), Raghothama Chaerkady (Author), Junmin Wang (Author), Shao Huan Samuel Weng (Author), Chunlei Wang (Author), Chen Qian (Author), Lisa Cazares (Author), Sonja Hess (Author), Peter Amaya (Author), Jie Zhu (Author), Diane Hatton (Author)
• Format: Book
• Published: Taylor & Francis Group, 2022-12-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

With the aim of increasing protein productivity of Chinese hamster ovary (CHO) cells, we sought to generate new CHO hosts with favorable biomanufacturing phenotypes and improved functionality. Here, we present an innovative approach of enriching the CHO host cells with a high mitochondrial membrane...