Co-expression in tissue-specific gene networks links genes in cancer-susceptibility loci to known somatic driver genes

• Main Authors: Carlos G. Urzúa-Traslaviña (Author), Tijs van Lieshout (Author), Floranne Boulogne (Author), Kevin Domanegg (Author), Mahmoud Zidan (Author), Olivier B. Bakker (Author), Annique Claringbould (Author), Jeroen de Ridder (Author), Wilbert Zwart (Author), Harm-Jan Westra (Author), Patrick Deelen (Author), Lude Franke (Author)
• Format: Book
• Published: BMC, 2024-07-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Abstract Background The genetic background of cancer remains complex and challenging to integrate. Many somatic mutations within genes are known to cause and drive cancer, while genome-wide association studies (GWAS) of cancer have revealed many germline risk factors associated with cancer. However,...