Synthesis and biological evaluation of anti-Toxoplasma gondii activity of a novel scaffold of thiazolidinone derivatives

• Main Authors: Simone Carradori (Author), Daniela Secci (Author), Bruna Bizzarri (Author), Paola Chimenti (Author), Celeste De Monte (Author), Paolo Guglielmi (Author), Cristina Campestre (Author), Daniela Rivanera (Author), Claudia Bordón (Author), Lorraine Jones-Brando (Author)
• Format: Book
• Published: Taylor & Francis Group, 2017-01-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

We designed and synthesised novel N-substituted 1,3-thiazolidin-4-one derivatives for the evaluation of their anti-Toxoplasma gondii efficacy. This scaffold was functionalised both at the N1-hydrazine portion with three structurally different moieties and at the lactam nitrogen with substituted benz...