Screen for abnormal mitochondrial phenotypes in mouse embryonic stem cells identifies a model for succinyl-CoA ligase deficiency and mtDNA depletion

Mutations in subunits of succinyl-CoA synthetase/ligase (SCS), a component of the citric acid cycle, are associated with mitochondrial encephalomyopathy, elevation of methylmalonic acid (MMA), and mitochondrial DNA (mtDNA) depletion. A FACS-based retroviral-mediated gene trap mutagenesis screen in m...

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Bibliographic Details
Main Authors: Taraka R. Donti (Author), Carmen Stromberger (Author), Ming Ge (Author), Karen W. Eldin (Author), William J. Craigen (Author), Brett H. Graham (Author)
Format: Book
Published: The Company of Biologists, 2014-02-01T00:00:00Z.
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3rd Floor Main Library

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Call Number: A1234.567
Copy 1 Available