Carboxylesterase 1 family knockout alters drug disposition and lipid metabolism

• Main Authors: Changpei Gan (Author), Jing Wang (Author), Alejandra Martínez-Chávez (Author), Michel Hillebrand (Author), Niels de Vries (Author), Joke Beukers (Author), Els Wagenaar (Author), Yaogeng Wang (Author), Maria C. Lebre (Author), Hilde Rosing (Author), Sjoerd Klarenbeek (Author), Rahmen Bin Ali (Author), Colin Pritchard (Author), Ivo Huijbers (Author), Jos H. Beijnen (Author), Alfred H. Schinkel (Author)
• Format: Book
• Published: Elsevier, 2023-02-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

The mammalian carboxylesterase 1 (Ces1/CES1) family comprises several enzymes that hydrolyze many xenobiotic chemicals and endogenous lipids. To investigate the pharmacological and physiological roles of Ces1/CES1, we generated Ces1 cluster knockout (Ces1-/-) mice, and a hepatic human CES1 transgeni...