Carboxylesterase 1 family knockout alters drug disposition and lipid metabolism
The mammalian carboxylesterase 1 (Ces1/CES1) family comprises several enzymes that hydrolyze many xenobiotic chemicals and endogenous lipids. To investigate the pharmacological and physiological roles of Ces1/CES1, we generated Ces1 cluster knockout (Ces1-/-) mice, and a hepatic human CES1 transgeni...
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Elsevier,
2023-02-01T00:00:00Z.
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