Enhanced Anti-diabetic Effect of Berberine Combined With Timosaponin B2 in Goto-Kakizaki Rats, Associated With Increased Variety and Exposure of Effective Substances Through Intestinal Absorption

• Main Authors: Xiaoting Tian (Author), Fang Liu (Author), Zhixiong Li (Author), Yunfei Lin (Author), Huan Liu (Author), Pei Hu (Author), Mingcang Chen (Author), Zhaolin Sun (Author), Zhou Xu (Author), Yiting Zhang (Author), Li Han (Author), Yuanyuan Zhang (Author), Guoyu Pan (Author), Chenggang Huang (Author)
• Format: Book
• Published: Frontiers Media S.A., 2019-01-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Objective: Inspired by the traditionally clinical application of herb pair Zhimu-Huangbo to treat diabetes, a combination of plant ingredients, timosaponin B2 (TB-2) and berberine (BBR), was evaluated for their anti-diabetic efficacy and cooperative mechanisms.Methods: The efficacy and pharmacokinet...