Identification of Dihydropyrazolo[1,5-<i>a</i>]pyrazin-4(5<i>H</i>)-ones as Cyclic Products of β-Amidomethyl Vinyl Sulfone Alphavirus Cysteine Protease Inhibitors

• Main Authors: Anirban Ghoshal (Author), Álvaro F. Magalhães (Author), Kesatebrhan Haile Asressu (Author), Mohammad Anwar Hossain (Author), Matthew H. Todd (Author), Timothy M. Willson (Author)
• Format: Book
• Published: MDPI AG, 2024-06-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Optimized syntheses of (<i>E</i>)-5-(2-ethoxyphenyl)-<i>N</i>-(3-(methylsulfonyl)allyl)-1<i>H</i>-pyrazole-3-carboxamide (RA-0002034, <b>1</b>), a promising antiviral covalent cysteine protease inhibitor lead, were developed. The syntheses avoid the co...