Processing Parameters and Ion Excipients Affect the Physicochemical Characteristics of the Stereocomplex-Formed Polylactide-b-Polyethylene Glycol Nanoparticles and Their Pharmacokinetics

• المؤلفون الرئيسيون: Kohei Ogawa (مؤلف), Hidemasa Katsumi (مؤلف), Yasushi Moroto (مؤلف), Masaki Morishita (مؤلف), Akira Yamamoto (مؤلف)
• التنسيق: كتاب
• منشور في: MDPI AG, 2022-03-01T00:00:00Z.
• الموضوعات: article
• الوصول للمادة أونلاين: Connect to this object online.

To optimize the characteristics of stereocomplex polylactide-b-polyethylene glycol nanoparticles (SC-PEG NPs) in terms of pharmacokinetics (PK), we chose continuous anti-solvent precipitation with a T-junction as a preparation method and investigated the effect of using solvents containing an ion ex...