Single cell transcriptomic profiling of large intestinal enteroendocrine cells in mice - Identification of selective stimuli for insulin-like peptide-5 and glucagon-like peptide-1 co-expressing cells

• Main Authors: Lawrence J. Billing (Author), Pierre Larraufie (Author), Jo Lewis (Author), Andrew Leiter (Author), Joyce Li (Author), Brian Lam (Author), Giles SH. Yeo (Author), Deborah A. Goldspink (Author), Richard G. Kay (Author), Fiona M. Gribble (Author), Frank Reimann (Author)
• Format: Book
• Published: Elsevier, 2019-11-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Objective: Enteroendocrine cells (EECs) of the large intestine, found scattered in the epithelial layer, are known to express different hormones, with at least partial co-expression of different hormones in the same cell. Here we aimed to categorize colonic EECs and to identify possible targets for...