Influence of methadone on clopidogrel in addicts on methadone maintenance therapy

• 主要な著者: Ferigol Fallah (著者), Abolhasan Hamidikenari (著者), Seyed Navid Sajadi (著者), Seyed Rohollah Sajadi (著者), Mohammad Reza Shiran (著者)
• フォーマット: 図書
• 出版事項: Babol University of Medical Sciences, 2016-04-01T00:00:00Z.
• 主題: article
• オンライン･アクセス: Connect to this object online.

Background: Clopidogrel is a prodrug that converts in the liver to an active thiol metabolite, which irreversibly inhibits the platelet P2Y12 adenosine diphosphate receptor. It seems that methadone as CYP2C19 inhibitor affects ticlopidine activity in vivo. This study aimed to test the ability of met...