Longitudinal Consumption of Ergothioneine Reduces Oxidative Stress and Amyloid Plaques and Restores Glucose Metabolism in the 5XFAD Mouse Model of Alzheimer's Disease

• Main Authors: Clayton A. Whitmore (Author), Justin R. Haynes (Author), William J. Behof (Author), Adam J. Rosenberg (Author), Mohammed N. Tantawy (Author), Brian C. Hachey (Author), Brian E. Wadzinski (Author), Benjamin W. Spiller (Author), Todd E. Peterson (Author), Krista C. Paffenroth (Author), Fiona E. Harrison (Author), Robert B. Beelman (Author), Printha Wijesinghe (Author), Joanne A. Matsubara (Author), Wellington Pham (Author)
• Format: Book
• Published: MDPI AG, 2022-06-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

<i>Background:</i> Ergothioneine (ERGO) is a unique antioxidant and a rare amino acid available in fungi and various bacteria but not in higher plants or animals. Substantial research data indicate that ERGO is a physiological antioxidant cytoprotectant. Different from other antioxidants...