Design, Synthesis, and Evaluation of Oleyl-WRH Peptides for siRNA Delivery

Design, Synthesis, and Evaluation of Oleyl-WRH Peptides for siRNA Delivery

Delivering nucleic acid therapeutics across cell membranes is a significant challenge. Cell-penetrating peptides (CPPs) containing arginine (R), tryptophan (W), and histidine (H) show promise for siRNA delivery. To improve siRNA delivery and silence a model STAT3 gene, we hypothesized that oleyl acy...

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Main Authors: Mrigank Shekhar Rai (Author), Muhammad Imran Sajid (Author), Jonathan Moreno (Author), Keykavous Parang (Author), Rakesh Kumar Tiwari (Author)
Format: Book
Published: MDPI AG, 2024-08-01T00:00:00Z.
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