Novel hits for acetylcholinesterase inhibition derived by docking-based screening on ZINC database

• Main Authors: Irini Doytchinova (Author), Mariyana Atanasova (Author), Iva Valkova (Author), Georgi Stavrakov (Author), Irena Philipova (Author), Zvetanka Zhivkova (Author), Dimitrina Zheleva-Dimitrova (Author), Spiro Konstantinov (Author), Ivan Dimitrov (Author)
• Formato: Livro
• Publicado em: Taylor & Francis Group, 2018-01-01T00:00:00Z.
• Assuntos: article
• Acesso em linha: Connect to this object online.

The inhibition of the enzyme acetylcholinesterase (AChE) increases the levels of the neurotransmitter acetylcholine and symptomatically improves the affected cognitive function. In the present study, we searched for novel AChE inhibitors by docking-based virtual screening of the standard lead-like s...