Concomitant heterochromatinisation and down-regulation of gene expression unveils epigenetic silencing of <it>RELB </it>in an aggressive subset of chronic lymphocytic leukemia in males

• Main Authors: Marteau Jean-Brice (Author), Rigaud Odile (Author), Brugat Thibaut (Author), Gault Nathalie (Author), Vallat Laurent (Author), Kruhoffer Mogens (Author), Orntoft Torben F (Author), Nguyen-Khac Florence (Author), Chevillard Sylvie (Author), Merle-Beral Hélène (Author), Delic Jozo (Author)
• Format: Book
• Published: BMC, 2010-11-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

<p>Abstract</p> <p>Background</p> <p>The sensitivity of chronic lymphocytic leukemia (CLL) cells to current treatments, both <it>in vitro </it>and <it>in vivo</it>, relies on their ability to activate apoptotic death. CLL cells resistant to DNA d...