Predicting disruptions to drug pharmacokinetics and the risk of adverse drug reactions in non-alcoholic steatohepatitis patients

• Main Authors: Solène Marie (Author), Kayla L. Frost (Author), Raymond K. Hau (Author), Lucy Martinez-Guerrero (Author), Jailyn M. Izu (Author), Cassandra M. Myers (Author), Stephen H. Wright (Author), Nathan J. Cherrington (Author)
• Format: Book
• Published: Elsevier, 2023-01-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

The liver plays a central role in the pharmacokinetics of drugs through drug metabolizing enzymes and transporters. Non-alcoholic steatohepatitis (NASH) causes disease-specific alterations to the absorption, distribution, metabolism, and excretion (ADME) processes, including a decrease in protein ex...