Retinal Neurotoxicity of Nitric Oxide Donors With Different Half-Life of Nitric Oxide Release: Involvement of N-Methyl-D-aspartate Receptor

• Auteurs principaux: Kazue Takahata (Auteur), Hiroshi Katsuki (Auteur), Toshiaki Kume (Auteur), Ken Ito (Auteur), Yoshinaga Tochikawa (Auteur), Shizuko Muraoka (Auteur), Fumio Yoneda (Auteur), Satoshi Kashii (Auteur), Yoshihito Honda (Auteur), Akinori Akaike (Auteur)
• Format: Livre
• Publié: Elsevier, 2003-01-01T00:00:00Z.
• Sujets: article
• Accès en ligne: Connect to this object online.

We compared the degree of neurotoxic outcome in the retina exposed to three nitric oxide (NO) donors with different half-life of NO release. Intravitreal injection of NO donors resulted in a significant decrease in cell density in the ganglion cell layer and thinning of the inner plexiform layer in...