Retinal Neurotoxicity of Nitric Oxide Donors With Different Half-Life of Nitric Oxide Release: Involvement of N-Methyl-D-aspartate Receptor

• Main Authors: Kazue Takahata (Author), Hiroshi Katsuki (Author), Toshiaki Kume (Author), Ken Ito (Author), Yoshinaga Tochikawa (Author), Shizuko Muraoka (Author), Fumio Yoneda (Author), Satoshi Kashii (Author), Yoshihito Honda (Author), Akinori Akaike (Author)
• Format: Book
• Published: Elsevier, 2003-01-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

We compared the degree of neurotoxic outcome in the retina exposed to three nitric oxide (NO) donors with different half-life of NO release. Intravitreal injection of NO donors resulted in a significant decrease in cell density in the ganglion cell layer and thinning of the inner plexiform layer in...