ADAR1 Alleviates Inflammation in a Murine Sepsis Model via the ADAR1-miR-30a-SOCS3 Axis

• Main Authors: Zhou Shangxun (Author), Li Junjie (Author), Zhao Wei (Author), Wang Yutong (Author), Jia Wenyuan (Author), Liu Shanshou (Author), Wang Yanjun (Author), Wang Qianmei (Author), Feng Zhusheng (Author), Yu Chaoping (Author), Zhuang Ran (Author), Yin Wen (Author), Huang Yang (Author)
• Format: Book
• Published: Hindawi Limited, 2020-01-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Adenosine deaminase acting on double-stranded RNA 1 (ADAR1) mediates adenosine-to-inosine (A-to-I) RNA editing events. ADAR1 is highly expressed in "septic" macrophages and in small intestinal tissues of mice with sepsis. Overexpression of ADAR1 suppresses inflammation and intestinal damag...