Lysosomal P-gp-MDR1 Confers Drug Resistance of Brentuximab Vedotin and Its Cytotoxic Payload Monomethyl Auristatin E in Tumor Cells

• Päätekijät: Peggy Liu-Kreyche (Tekijä), Hong Shen (Tekijä), Anthony M. Marino (Tekijä), Ramaswamy A. Iyer (Tekijä), W. Griffith Humphreys (Tekijä), Yurong Lai (Tekijä)
• Aineistotyyppi: Kirja
• Julkaistu: Frontiers Media S.A., 2019-07-01T00:00:00Z.
• Aiheet: article
• Linkit: Connect to this object online.

Antibody-drug conjugates (ADCs) are composed of an antibody linked to cytotoxic anticancer payloads. ADCs recognize tumor-specific cell surface antigens and are internalized into lysosomes where proteolytic enzymes release the cytotoxic payloads. Efflux transporters on plasma membrane that play a si...