Thrombomodulin induces anti-inflammatory effects by inhibiting the rolling adhesion of leukocytes in vivo

• Main Authors: Shino Nishizawa (Author), Junichi Kikuta (Author), Shigeto Seno (Author), Masahiro Kajiki (Author), Ryuichi Tsujita (Author), Hiroki Mizuno (Author), Takao Sudo (Author), Tomoka Ao (Author), Hideo Matsuda (Author), Masaru Ishii (Author)
• Format: Book
• Published: Elsevier, 2020-05-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Thrombomodulin (TM) is an integral membrane protein expressed on the surface of vascular endothelial cells that suppresses blood coagulation. Recent studies have shown that TM exhibits anti-inflammatory effects by inhibiting leukocyte recruitment. However, the actual modes of action of TM in vivo re...