Tricin promoted ATG-7 dependent autophagic degradation of α-synuclein and dopamine release for improving cognitive and motor deficits in Parkinson's disease

• Main Authors: Xingxia Wang (Author), Wei Hu (Author), Liqun Qu (Author), Jian Wang (Author), Anguo Wu (Author), Hang Hong Lo (Author), Jerome P.L. Ng (Author), Yong Tang (Author), Xiaoyun Yun (Author), Jianhui Wu (Author), Vincent Kam Wai Wong (Author), Sookja Kim Chung (Author), Linna Wang (Author), Weidan Luo (Author), Xiang Ji (Author), Betty Yuen Kwan Law (Author)
• Format: Book
• Published: Elsevier, 2023-10-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Tricin, a natural nontoxic flavonoid distributed in grasses and euphorbia plants, has been reported to scavenge free radicals, possess anti-inflammatory and antioxidative effects. However, its autophagic effect on Parkinson's disease (PD) has not been elucidated. By adopting cellular and C. ele...