JBP485, A Dual Inhibitor of Organic Anion Transporters (OATs) and Renal Dehydropeptidase-I (DHP-I), Protects Against Imipenem-Induced Nephrotoxicity

Imipenem (IMP) possesses a broad spectrum of antibacterial activity; however, nephrotoxicity limits its clinical application in patients with renal insufficiency. In our previous studies, a dipeptide, JBP485, a dipeptide with the chemical structure cyclo-trans-4-L-hydroxyprolyl-L-serine, was found t...

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Main Authors: Chong Wang (Author), Changyuan Wang (Author), Jingjing Wu (Author), Qiang Meng (Author), Huan Jin (Author), Huijun Sun (Author), Taiichi Kaku (Author), Jing Chen (Author), Xiaokui Huo (Author), Kexin Liu (Author)
Format: Book
Published: Frontiers Media S.A., 2022-06-01T00:00:00Z.
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