JBP485, A Dual Inhibitor of Organic Anion Transporters (OATs) and Renal Dehydropeptidase-I (DHP-I), Protects Against Imipenem-Induced Nephrotoxicity

• Główni autorzy: Chong Wang (Autor), Changyuan Wang (Autor), Jingjing Wu (Autor), Qiang Meng (Autor), Huan Jin (Autor), Huijun Sun (Autor), Taiichi Kaku (Autor), Jing Chen (Autor), Xiaokui Huo (Autor), Kexin Liu (Autor)
• Format: Książka
• Wydane: Frontiers Media S.A., 2022-06-01T00:00:00Z.
• Hasła przedmiotowe: article
• Dostęp online: Connect to this object online.

Imipenem (IMP) possesses a broad spectrum of antibacterial activity; however, nephrotoxicity limits its clinical application in patients with renal insufficiency. In our previous studies, a dipeptide, JBP485, a dipeptide with the chemical structure cyclo-trans-4-L-hydroxyprolyl-L-serine, was found t...