JBP485, A Dual Inhibitor of Organic Anion Transporters (OATs) and Renal Dehydropeptidase-I (DHP-I), Protects Against Imipenem-Induced Nephrotoxicity

• Main Authors: Chong Wang (Author), Changyuan Wang (Author), Jingjing Wu (Author), Qiang Meng (Author), Huan Jin (Author), Huijun Sun (Author), Taiichi Kaku (Author), Jing Chen (Author), Xiaokui Huo (Author), Kexin Liu (Author)
• Format: Book
• Published: Frontiers Media S.A., 2022-06-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Imipenem (IMP) possesses a broad spectrum of antibacterial activity; however, nephrotoxicity limits its clinical application in patients with renal insufficiency. In our previous studies, a dipeptide, JBP485, a dipeptide with the chemical structure cyclo-trans-4-L-hydroxyprolyl-L-serine, was found t...