JBP485, A Dual Inhibitor of Organic Anion Transporters (OATs) and Renal Dehydropeptidase-I (DHP-I), Protects Against Imipenem-Induced Nephrotoxicity

• Váldodahkkit: Chong Wang (Dahkki), Changyuan Wang (Dahkki), Jingjing Wu (Dahkki), Qiang Meng (Dahkki), Huan Jin (Dahkki), Huijun Sun (Dahkki), Taiichi Kaku (Dahkki), Jing Chen (Dahkki), Xiaokui Huo (Dahkki), Kexin Liu (Dahkki)
• Materiálatiipa: Girji
• Almmustuhtton: Frontiers Media S.A., 2022-06-01T00:00:00Z.
• Fáttát: article
• Liŋkkat: Connect to this object online.

Imipenem (IMP) possesses a broad spectrum of antibacterial activity; however, nephrotoxicity limits its clinical application in patients with renal insufficiency. In our previous studies, a dipeptide, JBP485, a dipeptide with the chemical structure cyclo-trans-4-L-hydroxyprolyl-L-serine, was found t...