The Mitochondrial Na+/Ca2+ Exchanger Inhibitor CGP37157 Preserves Muscle Structure and Function to Increase Lifespan and Healthspan in Caenorhabditis elegans

• Autors principals: Paloma García-Casas (Autor), Pilar Alvarez-Illera (Autor), Eva Gómez-Orte (Autor), Juan Cabello (Autor), Rosalba I. Fonteriz (Autor), Mayte Montero (Autor), Javier Alvarez (Autor)
• Format: Llibre
• Publicat: Frontiers Media S.A., 2021-06-01T00:00:00Z.
• Matèries: article
• Accés en línia: Connect to this object online.

We have reported recently that the mitochondrial Na+/Ca2+ exchanger inhibitor CGP37157 extends lifespan in Caenorhabditis elegans by a mechanism involving mitochondria, the TOR pathway and the insulin/IGF1 pathway. Here we show that CGP37157 significantly improved the evolution with age of the sarco...